Loma Linda University

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Xiao Mao, MD
Assoc Res Prof, Basic Sciences
School of Medicine
Assoc Res Prof, Radiation Medicine
School of Medicine
Research & Grantsmanship    Funded Research Project (PI)
  • Stereological quantitative study of dose response of rat retina and choroids following proton and Iron-56 irradiation ( 7/2007 - 6/2010 )
  • Quantitative evaluation of AEOl10113 on radiation in brain tumor vasculature model ( 9/2006 - 7/2007 )
  • Cell loss in radiated retina: correlation with doses ( 5/2007 )
  • Three-dimensional analysis and visualization of rat brain capillary network ( 4/2007 )
  • To Study DNA double strand breaks following irradiation on a proliferative retinal microvessel model ( 7/2004 - 6/2005 )
  Funded Research Project (CI)
  • Confocal Laser Scanning Computer Assisted Stereology to quantify (PI Archambeau) ( 7/2007 - 6/2010 )
  • Progressive Alterations of Central Nervous System Structure and Function Are Caused by Charged Particle Radiation(PI: Greg Nelson) ( 6/2005 - 12/2008 )
  • Quantification of the Dose Response of Microvessel Parameters in the Retina, the Brain Cortex, and White Matter Following Iron-56 and Proton Irradiation. (PI: John Archambeau) ( 7/2004 - 6/2008 )
  • Determination of the capability of the radiation protector, manganic porphyrin, to protect the rectal mucosa of the rat from late radiation population changes(PI: John Archambeau) ( 1/2006 - 12/2007 )
  • Preclinical Development of Metalloporphyrin Antioxidant Mimetic for Prostate Cancer Therapy ( 5/2007 )
  • Quantification of the Dose Response of Microvessel Parameters in the Retina, the Brain Cortex, and White Matter Following Iron-56 and Proton Irradiation(PI: John Archambeau) ( 7/2005 - Present )
  Grant Proposals--Funded
  • Radiation-induced oxidative stress in retinal degeneration and radioprotective effect of a metalloporphyrin compound in rat retinal model ( 2/2009 - 2/2010 )
  Grant Proposals--Submitted
  • Quantitative evaluation of a metalloporphyrin antioxidant wiht proton radaition in a glioblastoma model ( 11/2008 - 10/2010 )
  • Mechanism in stress response of low dose ionizing radiation in a mouse skin model-NIH ( 10/2009 - 9/2010 )
  Abstracts Reporting Research -- Peer Reviewed
  • M.J. Pecaut, S. Mehrotra, E.J.M. Bayeta, X. Luo-Owen, C. Perez, S. Rightnar, G. Harding, L. Ortloff,  P. Gifford, X.W. Mao, D.L. Bellinger and D. S. Gridley. The Impact of Body-Only Proton Radiation on Immune-CNS Communication. PNIRS, San Diego, 2012.

    Lucie Kubínová, Ji?í Janáček, Petr Karen, Oleksandr Chernyavskiy, X. W. Mao, Ida Eržen, Marie Jirkovská. Estimation of geometrical characteristics of blood capillary network and their visualization by 3D mapping. Microscopy & Microanalysis, 2012.

    Mao XW and Gridley DS. Role of NADPH oxidase in low-dose radiation-induced neurovascular remodeling in mouse hippocampus. 23th annual NASA Space Radiation Investigators’ Workshop, Durham, North Carolina, 2012.

    ( 1/2012 - 12/2012 )
  • Mao XW, PecautMJ, Stodieck LS, Ferguson VL, Bateman TA,  Jones TA, Moldovan M, Cunningham C,  Chieu J, Slater JM, Gridley DS. Space flight environment induced-mitochondrial oxidative damage in ocular tissue. 58th Radiation Research Society, Puerto Rico, 2012.

    Mao XW, Gridley DS, Role of NADPH oxidase in low-dose radiation-induced neurovascular remodeling in mouse hippocampus. 23rd Annual NAA Space Radiation Investigators’ Workshop, Durham, North Carolina, 2012.

    ( 1/2012 - 12/2012 )
  • Mao XW, Mekonnen T, Gridley DS,Detection of early-stage apoptosis-associated protein expression profiles in mouse brain after low-dose of gamma irradiation. Heavy Ions in Therapy and Space Symposium, May 26-31, 2011, Shanghai, China.

    Pecaut MJ, Mao XW, Stodieck LS, Ferguson V, Bateman TA, Luo-Owen X, Mehrotra S, Bayeta E, Jones T, Ortloff L, Perez C, Bianski B, Reyes J, Ngo J, Ritter L, Harding G, Slater JM, Gridley DS. The Effects of the Spaceflight Environment on Immune Parameters.  Presented at the joint meeting of the American Society for Gravitational and Space Biology (27th Annual) and the International Society for Gravitational Physiology (32nd Annual). San Jose, CA., Abstract book pp. 96. November 3-6, 2011.

    ( 1/2011 - 12/2012 )
  • 34. Jeff Kao, Xiao Wen Mao, Andy Obenaus, Sheng-Kwei Song.. "Radiation induced injury of the lens and retina in rat eyes: Assessment with diffusion tensor imaging." ISMRM 14th Scientific Meeting . (2006): -. ( 4/2006 )
  • Xiao Wen Mao. "Charged particle irradiation causes a progressive loss of cells and a remodeling of CNS tissue as a function of dose, time and LET:A Progress report." 4ISWRR . (2006): -. ( 1/2006 )
  • Mao XW, Archambeau P, Baqai W, Larsen S and Archambeau J. "A quantification study of brain vasculature to iron irradiation using stereology." 53th Annual Meeting of Radiation Research Society, Denver, 2005 . (2005): -. ( 11/2005 )
  • 37. Mao XW, Archambeau JO, Archambeau P, Mekonnen T, and Larsen S,. "Stereological analysis of dose response of microvessel parameter in brain to iron and Proton Irradiation: a progress report." Radiation Research . (1969): -. (*)
  • Mao XW, Archambeau JO, Archambeau P, Mekonnen T, and Larsen S, . "Stereological analysis of dose response of microvessel parameter in brain to iron and Proton Irradiation: a progress report.." Radiation Research society . (): -. (*)
  • Xiao Wen Mao, Tsehay Mekonnen, James Crapo and John Archambeau.. "Effect of metalloporphyrin antioxidant on endothelial cells following irradiation." Cancer Research . (): -. (*)
  • 40. Xiao Wen Mao, Tsehay Mekonnen, James Crapo and John Archambeau. "Effect of metalloporphyrin antioxidant to reduce the radiation population damage in rat retinal following proton irradiation: A pilot study." Radiation Research . (): -. (*)
  • 41. X.W. Mao, L. Kubinova, J. Janacek, T. Mekonnen, N. Lindsay and J.O. Archambeau. "Dose Response of Brain Vasculature to Proton Irradiation: a Progress Report." NASA workshop . (): -. (*)
  • 42. Xiao Wen Mao, Cecile Favre, Michael J. Pecaut, and Greg Nelson. "Stereological Quantification of Rat Brain Vascular Population Following Iron Ion Radiation: a Progress Report. ." NASA workshop . (): -. (*)