Loma Linda University

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Eileen Brantley, PhD
Assistant Professor, Basic Sciences
School of Medicine
Assistant Professor, Pharmaceutical and Administrative Sciences
School of Pharmacy
Education 
BS, 6/1993, Oakwood University
With Honors
MS, 8/1995, Ohio State Univ Main Campus
PhD, 10/1999, Meharry Medical College
 

 

In this dissertation research project, we synthesized cyanostilbenes using the Claisen-Schmidt condensation reaction and characterized them with GC/MS and TLC analyses. We then evaluated the cyanostilbenes for in vitro antitumor activity. We demonstrated that cyanostilbenes with anti-tumor activity were able to inhibit the growth of estrogen receptor-positive and estrogen receptor-negative breast cancer cells in part by arresting cell cycle progression and inhibiting tubulin polymerization in these cells.